Local score

Quantitative trait loci (QTL) with small effects, which are pervasive in quantitative phenotypic variation, are difficult to detect in genome-wide association studies (GWAS). To improve their detection, we propose to use a local score approach that accounts for the surrounding signal due to linkage disequilibrium, by accumulating association signals from contiguous single markers.

We also updated the scripts, so now is possible to compute the distribution of the local score for xi= 3 and 4, under the assumption that the p-values follow a uniform distribution.

Reference:

• A local score approach improves GWAS resolution and detects minor QTL: application to Medicago truncatula quantitative disease resistance to multiple Aphanomyces euteiches isolates https://www.nature.com/articles/s41437-019-0235-x